Most of us are familiar with the relationship between diuretics and increased uric acid levels potentially precipitating attacks of gout. Perhaps fewer recall that beta blockers also increase uric acid levels. In contrast, calcium channel blockers (CCBs) and losartan have been observed to decrease serum uric acid levels.
In contrast, current use of diuretics, beta blockers, ACE-inhibitors, and non-losartan ARBs among those with hypertension were all associated with an increased risk of incident gout. Findings were similar among patients without hypertension and among those on anti-gout medications.
Preventing Gout With Anti-Hypertensives: Selecting the Right Agent | MDedge Internal Medicine https://tinyurl.com/y8e2jvsn
